Student sample for assessment
Written by a Year 10 student in Launceston, Tasmania, Australia.
Antibiotic resistance occurs when bacteria evolve mechanisms that allow them to survive exposure to antibiotics that would previously have killed them. Resistance develops through natural selection: when a population of bacteria is exposed to an antibiotic, most die, but those with genetic mutations that confer resistance survive and reproduce. Over time, the resistant population expands and the antibiotic becomes less effective. Resistance can also spread between bacteria through a process called horizontal gene transfer, in which bacteria exchange genetic material directly. This means that resistance can spread not only within a species but between different species of bacteria. The main causes of antibiotic resistance are the overuse and inappropriate use of antibiotics in human medicine and in agriculture. In human medicine, resistance is driven by practices including the prescribing of antibiotics for viral infections, against which they have no effect, and the failure of patients to complete prescribed courses, which can leave resistant bacteria alive. In agriculture, antibiotics are used routinely in livestock production — both to treat and prevent disease and, historically, as growth promoters. This widespread use creates selection pressure on bacteria across animal populations and can transmit resistance to humans through food chains. The World Health Organization has identified antimicrobial resistance as one of the ten most significant global public health threats. The consequences of increasing resistance are serious and the responses required are wide-ranging. If currently effective antibiotics cease to function, routine medical procedures including surgery, chemotherapy and the treatment of common infections will become significantly more dangerous. Responses include the development of new antibiotics, the regulation of antibiotic use in both medicine and agriculture, and international coordination through initiatives such as the WHO’s Global Action Plan on Antimicrobial Resistance. Slowing the development of resistance requires both clinical behaviour change and structural reform to how antibiotics are produced, prescribed and used at a global scale.